Hemorrhagic Stroke

Life-threatening but scarce treatment

Hemorrhagic stroke carries a high risk of disability and mortality worldwide. Vascular malformations of the central nervous system are refractory cerebrovascular structural abnormalities that lead to hemorrhagic stroke in children and young adults. Revealing the bleeding mechanism and intervening in the occurrence of bleeding events are the key problems to be solved in this disease.

​​​​​​Genetic cause

We take the lead in discovering that somatic mutations of KRAS, BRAF, MAP3K3 and PIK3CA are the initiating factors of the disease.

​​​​​​Mouse model

We build typical human-mimicking animal models to investigate the pathophysiology of vascular malformations and intracerebral hemorrhage.

​​​​​​Pathological Mechanism

By utilizing the organoid platform and a multi-omics research approach, we aim to gain a new understanding of the development and bleeding of vascular malformations and neuroinflammation after intracerebral hemorrhage.

Treatment

Through mechanistic studies, we aim to discover novel therapeutic drugs for inhibiting the initiation, progression, and bleeding of vascular malformations and treatment of intracerebral hemorrhage.